Mechanism of Action of Anti-CTLA4

This 6-minute animation examines recent advancements in immunotherapy that harness the power and specificity of the immune system to fight cancer.
New insights are provided on the mechanisms of T lymphocyte regulation and the role of CTLA4, a T cell receptor that functions as a “natural brake” on the immune system.
The development of monoclonal antibodies directed against CTLA4 are also discussed in detail.
This opening scene features several activated T cells attacking rapidly dividing cancer cells of a tumor, followed by a zoom up to the surface of one of the activated T cells.