Pathophysiology of sickle cell disease

Segment from a 4-minute animation that explores the pathophysiology of sickle cell disease and the progressive, tissue-damaging effects of chronic hemolysis and anemia. Our assignment: visually depict several key critical aspects of the SCD story, such as hemoglobin S (HbS) polymerization, red blood cell sickling and tethering, vaso-occlusion, and chronic hemolysis. Sickled red blood cells promote inflammation, obstruct the vasculature, injure…
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Medscape Openers

We are thrilled to be collaborating on openers for Medscape. Over the past four years, Hybrid has successfully produced more than 130 videos. Below are some outstanding examples of the openers we’ve created. Below are a few images from the animations created.
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Cancer’s Micro World

Take an immersive, cinematic journey through this thriving tumor microenvironment, showcasing the intricate biological landscape of an extracellular matrix, newly-forming blood vessels, cancer-associated fibroblasts, and various immune cells such as macrophages, T cells, B cells, dendritic cells, neutrophils, NK cells, and more.
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