Project: HbS Polymerization & Sickle Cell Disease (MOD)

Segment from 4-minute (MOD) animation that discusses the pathophysiology of sickle cell disease and the silent damage of SCD that can go unrecognized.

Above: a view of sickle cells and chronic hemolysis underway.

We were challenged to visually depict several key critical aspects of the SCD story, such as hemoglobin S (HbS) polymerization, red blood cell sickling and tethering, vaso-occlusion, and chronic hemolysis.

Sickled red blood cells promote inflammation, obstruct the vasculature, injure the endothelium, and may lead to ischemic damage in vital organs.

SCD is one of the most common inherited diseases worldwide.