Cancer’s Micro World

Cancer’s Micro World

Project: A closer look at the tumor microenvironment This animation delves deep into the tumor microenvironment (TME) — a complex cellular domain in which a tumor resides. Take an immersive, cinematic journey through this thriving tumor microenvironment, showcasing the intricate biological landscape of an extracellular matrix, newly-forming blood vessels, cancer-associated fibroblasts, and various immune cells…

Monoclonal antibodies

Monoclonal antibodies

Project: Targeting multiple myeloma with monoclonal antibodies The monoclonal antibody has become instrumental for the treatment of multiple myeloma. In this sequence, monoclonal antibodies have targeted CD38, a protein commonly expressed on the surface of cancerous plasma cells. Above: Monoclonal antibodies target CD38, a protein commonly expressed on the surface of cancerous plasma cells A…

Carcinoid Syndrome

Carcinoid Syndrome

Project: Sandostatin® LAR Depot MOA This sequence is an excerpt from a 5-minute MOA animation that examines the hypersecretion of hormones in carcinoid syndrome and an advanced biodegradable drug delivery system using polymer microsphere technology and slow release of octreotide. Above: assembly of a biodegradable glucose polymer microsphere Our client gave us a few unique challenges: depict…

Multiple Myeloma

Multiple Myeloma

Project: mAb targeting multiple myeloma MOASequence from 5-minute MOA that provides insight and details for a monoclonal antibody (mAb) designed to induce programmed tumor cell death (apoptosis) and immunomodulatory activity.  Above: Monoclonal antibodies designed to induce programmed tumor cell death (apoptosis) and immunomodulatory activity. For this mechanism of action video, our task was to create…

CAR T Therapy

CAR T Therapy

Project: A Closer Look at ABECMA® CAR T Cell Therapy A few selected segments from a 6-minute animation created for a first-in-class B-cell maturation antigen (BCMA)-directed personalized immunotherapy called chimeric antigen receptor (CAR) T-cell therapy. Above: T cells targeting protein BCMA In this CAR T therapy, the T cells are engineered to target a protein…