The promise of antibody drug conjugates

Jul 02, 2020
What if instead of using traditional chemotherapy, antibodies could deliver a drug payload directly to tumor cells — and spare the normal cells?
In this sequence, antibody-drug conjugates can be seen here in the airway, descending down to cancerous epithelial cells and binding to specific antigens only found on targeted cells.
Monoclonal antibody technologies continue to evolve and hold great promise for the treatment of a wide number of diseases.

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mAb targeting multiple myeloma

Feb 22, 2022

Sequence from 5-minute MOA that provides insight and details for a monoclonal antibody (mAb) designed to induce programmed tumor cell death (apoptosis) and immunomodulatory activity.

For this mechanism of action video, our task was to create a science story that would depict several key features: how the mAb finds and binds to myeloma cells and exposes them for elimination, how it boosts cells of the immune system, and how this targeted immunotherapy can kill myeloma cells directly.

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CD38 antibodies inducing cell death

Feb 20, 2022

The monoclonal antibody has become instrumental for the treatment of multiple myeloma.

In this sequence, monoclonal antibodies are seen targeting CD38, a protein commonly expressed on the surface of cancerous plasma cells.

Activation of the complement system triggers the formation of pores in the cellular membrane, leading to cell death.

A goal for this sequence was to explore a visual approach that resembled a deep sea look & feel, including planktonic soft-bodied organisms and other invertebrate animals that live near the ocean floor.

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