Sickle cell vaso-occlusion

Nov 02, 2020

Here inside this blood vessel, the circulation of red blood cells is obstructed by sickled red blood cells aggregating, sticking together, and leading to an event known as a vaso-occlusive crisis — a central characteristic of sickle cell disease (SCD)
As we zoom out, we are able to see more damage being done in other microvessels.

Sickled red blood cells promote inflammation, obstruct the vasculature, injure the endothelium, and may lead to ischemic damage in vital organs.

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Augmented Reality – Gross Bodies

Sep 20, 2020

Working closely with local book company Lerner Publishing Group, we developed an augmented reality app geared for student learning. This app includes series Space in Action, Gross Bodies and Creepy Crawlies. All now available in stores.

Take a look!

View Demo >>

Download IOS App >>

Download Android App >>

Antibody-drug conjugates

Jul 02, 2020
What if instead of using traditional chemotherapy, antibodies could deliver a drug payload directly to tumor cells — and spare the normal cells?
In this sequence, antibody-drug conjugates can be seen here in the airway, descending down to cancerous epithelial cells and binding to specific antigens only found on targeted cells.
Monoclonal antibody technologies continue to evolve and hold great promise for the treatment of a wide number of diseases.

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Birth of a chimeric antigen receptor

Apr 02, 2020

Watch a chimeric antigen receptor (CAR) sprout from the surface of a genetically re-engineered white blood cell.

A chimeric antigen receptor (CAR) sprouts from the surface of a genetically re-engineered white blood cell.

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Latest promotional reel

Feb 20, 2020
We are thrilled to share our newest promotional reel with you . . .
. . . a collection of some of our favorite and latest work, featuring segments from medical animation projects we have produced over the past couple of years.

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11-foot-tall interactive beating heart installation

Jul 30, 2019

Large-scale, interactive installation featuring a beating heart and flow simulation of the body’s circulatory system.

The heartbeat and blood flow respond interactively to visitors in the facility: as more people enter the University Center, the heart rate elevates; as they leave, the heartbeat lowers. 

Created in the visual style of an MRI, the 11-foot-tall, 8-foot-wide installation serves as a living welcome to visitors of the Texas Tech Health Sciences Center.

This animation features a few of the sequences we produced for the final piece, including the particle simulations of blood pressure and flow.

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The Widespread Effects of Rheumatoid Arthritis

Jul 11, 2019

2.5 minute animation that explores the multiple factors contributing to joint inflammation in rheumatoid arthritis and the role of IL-6, one of the most abundant multifunctional cytokines in the synovial fluid of patients with RA.

IL-6 is a key driver of articular and systemic manifestations and major player in inflammation, immunity, and disease.

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Augmented Reality for Autotransfusion System

Jun 03, 2019

Augmented reality experience and app developed for the support of our client’s autotransfusion system. Developed as a key global training tool for service technicians, equipment service and support team members.

This in-depth AR experience allows the technician to virtually “place” the AutoLog IQ unit in their own space. Interactive callouts and a user interface help the user locate, examine, and disassemble device components, as well as re-assemble the system parts back into place. Imagine the benefits of this app versus having to locate the correct documentation and finding parts from a schematic.

Because the augmented device environment is a virtual mirror of the actual real-life system, this experience offers technicians the ability to take control of their learning process — on their own time, and at their own location. Videos are also available in the app to support the user experience.

A key for this project was to appropriate the system’s detailed CAD data and convert it into a reasonable format suitable for AR and real-time display.

Our role included all aspects, including close collaboration with the client on overall concept and creation of product’s augmented “story,” production of real-time 3D experience & assets, as well as interface design and deployment of app.

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Leveraging Augmented Reality for Medical Devices

Jan 12, 2019

Video capture of augmented reality app experience that highlights the features and benefits of our client’s innovative transcatheter pulmonary valve therapy device.

Our role included all aspects, including close collaboration with the client on overall concept and creation of product’s augmented “story,” production of real-time 3D experience & assets, as well as interface design and deployment of app.

Working closely with our client, we created an experience that provides the user with first-hand interaction of the device, as well as the ability to explore key features & benefits using a custom user interface design.

Frustrated by the limitations and prohibitive nature of taking prototypes and products on the road, our client is thrilled to now have an effective, high-quality augmented reality experience for use at various shows and events. Having the ability to instantly point out features and benefits using a self-contained AR device is a huge advantage.

Thanks to the immediacy, immersion, and presence that augmented reality provides, the advantages of leveraging the experience for patient education are amazing as well.

While AR and VR appear to be gaining ground in the areas of gaming and social media, healthcare and medical device industries are also beginning to realize their tremendous potential as well.

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New sensor technology that measures glucose levels in diabetes

Dec 14, 2018

Excerpt from animation elaborating on the science behind a new sensor technology that measures glucose levels in diabetes. The benefit of the device: no daily finger prick, and testing of glucose levels in a less painful and more efficient manner. Pretty cool.

In this sequence, we zoom down to the surface of the flexible filament to get a closer look at the micro cross-linked polymer matrix environment. As the camera travels through the matrix, glucose molecules can be seen landing, leading to signaling down the length of the cross-linked polymer chain, and reaching the floor of the sensor electrode.

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AnatomyAR+ kid workout with augmented reality

Sep 17, 2018

AnatomyAR+ augmented reality app for #MERGECube, available on MERGE Miniverse.

We made this video for our augmented reality app; featuring the most thoughtful (yet tough!) critics we could find. We are currently working on some updates and enhancements.

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Fungal infection in the blood

Jul 28, 2018

A breach in the skin (from a catheter) has led to an invasion of the bloodstream and profuse growth of the fungus.

Animation created for a closer look at Candida auris — the first identified multidrug-resistant fungus. Injury to cutaneous barriers by catheters allows yeast and fungi to invade deeper structures and enter the bloodstream.

We are honored and thrilled to have this artwork featured on the cover of this year’s Medical Illustration Sourcebook (30th ed).

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Let the phlegm fly!

Jul 08, 2018

Micro-landscape view of respiratory cells, an accumulating layer of mucus, and Bordetella pertussis bacteria releasing toxins.

A coughing event is occurring here, displacing mucus, the bacteria, and debris.

Also known as whooping cough, pertussis is a highly contagious airborne disease that spreads simply through the coughs and sneezes of an infected person.

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Burden of Genius excerpts

Mar 29, 2018

One of a few sequences we produced for the film “Burden of Genius.”

This documentary explores the life of Dr. Thomas Starzl, a man many call the greatest surgeon of the 20th century and “the father of modern transplantation.”

In 1967, Dr. Starzl stunned the world with the first successful liver transplantation.

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Immunotherapy in lung cancer

Feb 15, 2018

Activated T cells of the immune system targeting and destroying tumor cells. Once lysis occurs, the T cell moves to another cancer cell and repeats the process.

Sequence created for program that explores the impact of immunotherapies for lung cancer.

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Experience Virtual Inflammation in the Vive

Jan 02, 2018

VR experience examining the pathogenesis and inflammatory cycle of psoriatic arthritis.

What does virtual reality provide that a linear video cannot? For this MOA, we immerse the viewer into the inflammatory cycle of psoriatic arthritis and reiterate the story in a non-linear fashion — allowing users the ability to roam around and explore as they wish.

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Protecting against concussions

Dec 28, 2017

A couple of excerpts from a video production that explores a new advancement in preventing brain injury; specifically, the occurrence of brain injury caused by a concussive blow to the head.

The Q-Collar, developed by Q30 Innovations, assists the body’s own physiology, creating a “bubble-wrap” effect for the brain.

One key visual component of this project involved working closely with the client to execute their concept of slosh mitigation.

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New hybrid promotional reel

Nov 01, 2017

We are excited to release our new demo reel!

A collection of some of our favorite and latest work, featuring segments from medical animation projects we have produced over the past couple of years.

View video >>

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Augmented reality in the palm of your hand? Yes!

Jul 11, 2017

Earlier this summer, we were selected to be developers for the Merge Cube. The video below shows some explorations with augmented reality and the cube.

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4D Theater “Ride the Rails” Experience

Jul 11, 2017

A few selected segments from an 8-minute animation produced specially for client’s trade show “4D Multisensory” installation.

The 3D interactive ride was featured at the ATS International Conference, the home of pulmonary, critical care and sleep professionals. Attendees experienced a stereoscopic, 3D monorail-style journey through two “branded” cities, learning more about two different patient therapies for COPD.

The XD Theater Experience is a self-contained, motion-simulated, stereoscopic 3D interactive ride often implemented for high-end, media-based trade show attractions.

View online >>

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360° VR Demo

Apr 08, 2017

Some of our favorite work we have produced and explored in 360° VR.

View 360 here >> 

360° VR Pneumoniae

Jan 26, 2017

Frame from immersive 360° animation & illustration

View 360 here >>

Virtual and augmented reality demonstration

Aug 10, 2016

We were recently in Chicago to present a multi-device virtual and augmented reality showcase. The stations included the Vive, Oculus, Gear VR, Google Cardboard and the Hololens.

Contact us to schedule a demonstration.


ASCO Oculus Rift experience

Jun 22, 2016

Virtual Reality experience we produced for the ASCO 2016 conference.

View the Vr experience >>

Glass lungs

May 05, 2016

Animation of glass lungs and the bronchial pathways inside.

View the animation >>

3D cleaning technology

Mar 11, 2016

This 2-minute animation highlights product features for the first “smart” toothbrush, including new 3D
cleaning technology of the dynamic oscillating brush head design.

View the animation >>

Custom interaction with 3D content

Jan 29, 2016

At trade shows, you always want to present something that’s cool in order to get the attention of passersby. Whether it is real-time 3D using the Oculus rift, stereoscopid 3D or Leap Motion, Hybrid can develop the technology for your product.

Contact us to discuss custom experience >>

Virtual reality & real-time 3D promotional reel

Sep 26, 2015

Hybrid is working daily on projects that involve some aspect of leap motion, real-time 3D, virtual reality experience and/or augmentation. As immersive content and the latest emerging technologies become an every-day reality, our goal is to continue leading the way with our dedication to excellence, our artistic approach, and experience.

View the reel >>

Device Promotional Reel

Jun 30, 2015

We’ve brought together some of our favorite device-related work, featuring segments from projects we have produced over the past couple of years.

View the reel >>

Embrace-It! Live Action Video

Jun 19, 2015
Here are some sequences selected from Embrace-It!, an educational video that provides an overview of proper brushing and
flossing techniques for kids with braces.
Our challenges for this project included creating unique design options for the overall style, look & feel, animation and modelling,
and recreating proper brushing and flossing techniques in 3D.

View the animation >>

Journey into the body

May 15, 2015

The client’s challenge: using one fluid, dynamic camera move, “zoom into the eye and through the body in a way that will be intentionally vague overall — yet still have a couple of recognizable stops along the way.”

Rendered specially for a giant 26′ x 5′ screen, the animation was featured in an immersive geodesic dome installation.

View the animation >>

Mechanical Thrombectomy System

Apr 08, 2015

This 4-minute animation showcases the versatile design and broad indications of the Megavac and details how it separates
itself from the competition with the ability to be used for multiple applications.

View the animation >>

Shooting on location

Feb 18, 2015

Hybrid is on location for a project that will combine live action footage with CGI animation. This live-action shoot will be entirely on green-screen allowing us the ability to digitally reproduce the environment the actors are in. The environment can be anything from a sunny park, the surface of the moon, or in a micro environment.

View photo shoot >>

Cerebral Energy

Feb 06, 2015

Illustrations and MOA animation created for medical food that addresses diminished cerebral glucose metabolism (DCGM),
a critical aspect of  Alzheimer’s disease that leaves the brain thirsty for energy.

View Illustrations >>

Revamped Homepage

Jan 29, 2015

We’re excited to bring a unique new look for the front end of our website with looping movies created especially for the homepage.

Cycle through the four perfect loops by using the nodes in the upper right corner.

View Homepage >>


Dec 23, 2014

A view of a transcytosis underway.

In this depiction, we’ve developed our own hand-drawn cel-shading technique…

View Animation >>

Discovery Channel UK – “Ebola Exposed”

Dec 03, 2014

Title sequence – “Ebola Exposed” aired November 22 and created for Discovery Channel UK.

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The Science of G

Sep 13, 2014

Hybrid collaborated with VML (and client) to produce The Science of G, a new Gatorade product line.

View interactive experience >>

Malignant Cell

Aug 20, 2014

One of six cancer cell illustrations for large-scale trade show displays.

Also an entry into the Medical Illustrator’s Sourcebook.

View Illustration >>

The Life Cycle of the HIV Virus

Jun 17, 2014

This 3D interactive scene explains the puzzle of the HIV virus, its life cycle, and
how it reproduces itself in the host.

View life cycle >>

X-ray Body in Motion

Dec 13, 2013
A visual study/exploration of the body in motion with a focus on yoga poses.

View animation >>

Visual exploration of the heart

Mar 08, 2013

A visual study/exploration of the human heart.

View the animation >>

Synaptic Potential

Feb 21, 2013
Close-up view of a motor neuron, revealing its synaptic connections
from (potentially thousands) axon terminals of other neurons.

View full illustration>>

Make you itch

Sep 28, 2012

Close-up illustration of a head louse. The strands of hair help understand how large head lice really are.

View the short animation here >>

Medical Illustrators Sourcebook

Sep 06, 2011

Part of a large series of illustrations and animations created for a client. We’ve taken a couple of pieces from that project and created this art for the 2011 Medical Illustrator’s Sourcebook page and other promotional purposes.

View Full Double Page Spread >>

Anatomy reveal

Jun 30, 2011

An animated reveal of human anatomy.

We wanted to show the complexity and beauty of the human body
by blending between various passes and render styles.

View Animation >>

Nanotube Technology MOA

Jun 02, 2011

This is a sequence from a 3-minute animation that examines a unique formulation for building an effective therapy using the latest in nanotechnology, including monomers that organize into a controlled, self-assembling nanotube.

We worked very closely with our clients to deliver a detailed, accurate visualization of key attributes such as nanotube morphology, organization of dimers, and overall formation of the lanreotide nanotube.

View Full Project >>

Vertex Flowers

Apr 19, 2011

Collaborating with Vertex Pharmaceuticals, we came up with a way
to combine specific 3D renderings of chemical structures into photographs
depicting “everyday life” scenarios.

View Illustration >>


Aug 02, 2010

Animation produced for inclusion into the
Women’s Health area on the Mayo Clinic website.

Part of a series of animations where we have collaborated
with the Mayo Clinic Staff to help achieve a more high-end look to their animations.

View Animation >>

pH of Healthy Tears

Jul 03, 2010

This 2-minute animation examines the unique formulation
of Biotrue™, its ability to match the pH of healthy tears, and the
benefits of keeping tear proteins active.

View Animation >>


3D Tissue Valve

Dec 13, 2009

Frustrated by the limitations of a traditional product video shoot, our client
called on us to create a functioning photoreal 3D model of the Biocor tissue valve.

This allowed for far more dynamic camera moves and the ability to focus
more clearly on unique product features, such as the flexible stent,
composite construction, and unique shield design.

View Animation >>

Interactive Heart

Apr 12, 2008

With breakthroughs in science animation, Hybrid has helped people envision the
unobservable and the difficult-to-grasp for nearly ten years. With their latest
innovation, it’s you who reveals the beauty in science.

The Hybrid Interactive Heart animation offers viewers a hands-on, completely unique
experience in science visualization and conceptualization.

View Full Project >>