Deep in the lungs, we can see the clusters of tiny air sacs — the alveoli — becoming inflamed and filling with pus, making it difficult to breathe.

Pneumonia is an infection of the lungs caused by bacteria, viruses, or even fungi.

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Tagged: alveoli, anatomy, biology, hybrid medical, influenza animation, lung anatomy, lung health, medical animation, medical marketing, medical visualisation, Minneapolis Minnesota, pneumonia, pneumonia animation, pneumonia awareness, Pneumonia Day, pneumonia sucks, pneumonia vaccination, pneumonia vaccine, pulmonary, science, science visuals, scientific animation

Patient education animations created for WebMD that explore common medications for type 2 diabetes.

Because each treatment works in a unique way, our task was to bring three medications to life, creating an easy-to-understand mechanism of action story for each science story.

The three medications highlighted on the WebMD website: Metformin, Dipeptidyl Peptidase-4 (DPP-4), and SGLT2 Inhibitors. 

These are selected segments from the larger productions.

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Tagged: biology class, diabetes, diabetes 2, diabetes awareness, diabetes community, diabetes life, diabetes prevention, dpp4 inhibitor, hybrid medical, medical animation, medical visualisation, metformin, patient education, science art, science visuals, scientific animation, sglt2 inhibitor, type 2 diabetes, visual effects

Earlier this summer, we were selected to be developers for the Merge Cube. The video below shows some explorations with augmented reality and the cube.

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Tagged: AR, ARVRinEDU, augmented reality, biology, ed tech, extended reality, kids in AR, MERGE Cube, mixed reality, science education, science visuals, VR, XR

Sequence from immersive 1.5-minute 360° animation where we explore the benefits of sleep.

Here within the neural microspace of the brain, we depict the “cleansing system” of the brain: the glymphatic system. 

Just like the rest of your body, the brain accumulates waste. Recent discoveries have shown that cerebral spinal fluid “flushes” debris and metabolic toxins out of the neural microspace during the deep sleep phase. 

We also watch the heart beating (and lungs breathing) inside the chest cavity and discuss the role of sleep in reducing your risk for cardiovascular diseases.

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Tagged: 360 animation, benefits of sleep, biology, biomedical communications, biotech, daytime sleepiness, glymphatic system, healing power of sleep, hybrid medical, importance of sleep, insufficient sleep, medical animation, medical marketing, medical visualization, Minneapolis Minnesota, pharma, poor sleep, science visuals, scientific animation, sleep animation, sleep deprivation, sleep disorders, sleeplessness, WebMD animation

A few selected segments from an 8-minute animation produced specially for client’s trade show “4D Multisensory” installation.

The 3D interactive ride was featured at the ATS International Conference, the home of pulmonary, critical care and sleep professionals. Attendees experienced a stereoscopic, 3D monorail-style journey through two “branded” cities, learning more about two different patient therapies for COPD.

The XD Theater Experience is a self-contained, motion-simulated, stereoscopic 3D interactive ride often implemented for high-end, media-based trade show attractions.

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Tagged: 4D Multisensory, ATS International Conference, COPD, critical care, hybrid medical, interactive ride, mechanism of action, medical animation, pulmonary, science education, science visuals, scientific animation, sleep professionals, stereoscopic, stereoscopic 3D, trade show, tradeshow, XD Theater Experience

1.5-minute animation created for CME event. 

Our assignment included the development of the science story and creation of key events that would inform and educate viewers on the physiologic functions associated with the endocannabinoid system (ECS), the role of CB1 retrograde signaling, as well as the enzymes involved in the degradation of endocannabinoids.

We had the pleasure and honor of collaborating closely with the speaker of this event; she is also noted for her discovery of the CB1 receptor for cannabinoid agonists.

The target audience included neurologists, primary care physicians, and pediatricians.

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Tagged: anandamide, biology, biomedical communications, biotech, cannabinoid animation, cannabis, CB1, CB1 and CB2 receptors, ECS, endocannabinoid system, endocannabinoids, hybrid medical, medical animation, medical marketing, medical visualization, Minneapolis Minnesota, pharma, phytocannabinoids, presynaptic neuron, retrograde signaling, science visuals, scientific animation

We are excited to release our new demo reel!

A collection of some of our favorite and latest work, featuring segments from medical animation projects we have produced over the past couple of years.

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Tagged: demo reel, hybrid medical, medical animation, moa, pharma, promotional reel, science education, science visuals, scientific animation

A close-up fly-through of tumor cells, and the arrival of cytotoxic t cells intent on eradicating them. Activation and proliferation of cytotoxic T cells are critical for immune-mediated tumor destruction.

A key challenge we were given for this sequence: develop a rendering approach that mimics infrared thermal microscopy imaging techniques.

Researchers have been making advancements in understanding the thermal behavior of cells – for example, the ability to read the signatures of tumor cells due to their higher metabolism – in order to be used alongside existing histological analysis methods.

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Tagged: biology, biomedical communications, biotechnology, cancer cells, cytotoxic T cells, fluorescence microscopy, hybrid medical, immune cells, immunology, immunotherapy, infrared, infrared (IR) microscopy, infrared imaging in biology, infrared spectroscopy, IR imaging, IR microscopy, Killer T cell animation, Killer T cells, medical animation, microspectroscopic animation, Minneapolis Minnesota, oncology, pharma, science visuals, scientific animation, T cells, thermal, thermal imaging, thermal microscopy, tumor cells, tumor death

VR experience examining the pathogenesis and inflammatory cycle of psoriatic arthritis.

What does virtual reality provide that a linear video cannot? For this MOA, we immerse the viewer into the inflammatory cycle of psoriatic arthritis and reiterate the story in a non-linear fashion — allowing users the ability to roam around and explore as they wish.

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Tagged: ARVRinEDU, biology, ed tech, hybrid medical, immune system, immunology, immunotherapy, Interactive, medical VR, mixed reality, psoriatic arthritis, science education, science visuals, scientific animation, virtual reality, vive, VR

A few selected sequences we produced for a recent Medscape CME / ABIM MOC / CE symposium titled NASH 101: What You Need to Know Now

The full 2.5- minute animation was developed to be played as a visual aid when the moderator discussed epidemiology and pathogenesis.

We were asked to conceptualize and develop this visual science story. It provides insight into the pathophysiology of NAFLD and NASH, including the role of fatty acids, insulin resistance, and steatosis, as well as mitochondrial dysfunction, excess ROS production, and the stress put on the endoplasmic reticulum inside ballooning hepatocytes. 

In addition, we depicted key attributes of the progression of non-alcoholic steatohepatitis (NASH) including bloated hepatocytes and the fat droplets accumulating inside, displaced cell organelles, lobular inflammation, and the scarring (fibrosis) that occurs as collagen fibers fill the spaces once cell death occurs.

In the last few years, nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) have become the most common causes of chronic liver disease worldwide. This epidemic is starting to parallel the epidemics of obesity and type 2 diabetes.

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Tagged: biology, biomedical communications, cirrhosis, fatty acids, fatty liver disease animation, hepatocytes, hybrid medical, insulin resistance, lipotoxicity, liver animation, medical animation, medical marketing, NAFLD, NASH, non-alcoholic steatohepatitis, nonalcoholic fatty liver disease, obesity, science visuals, scientific animation, steatohepatitis, steatosis, type 2 diabetes

A couple of excerpts from a video production that explores a new advancement in preventing brain injury; specifically, the occurrence of brain injury caused by a concussive blow to the head.

The Q-Collar, developed by Q30 Innovations, assists the body’s own physiology, creating a “bubble-wrap” effect for the brain.

One key visual component of this project involved working closely with the client to execute their concept of slosh mitigation.

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Tagged: brain injury, concussion, hybrid medical, medical animation, science art, science visuals, scientific animation

A breach in the skin (from a catheter) has led to an invasion of the bloodstream and profuse growth of the fungus.

Animation created for a closer look at Candida auris — the first identified multidrug-resistant fungus. Injury to cutaneous barriers by catheters allows yeast and fungi to invade deeper structures and enter the bloodstream.

We are honored and thrilled to have this artwork featured on the cover of this year’s Medical Illustration Sourcebook (30th ed).

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Tagged: candida auris, candida infection, candidemia, candidiasis, drug resistant, fungal infection, fungus, hybrid medical, hyphae, medical animation, MedIllSB, microbiology, mycology, science art, science visuals

Activated T cells of the immune system targeting and destroying tumor cells. Once lysis occurs, the T cell moves to another cancer cell and repeats the process.

Sequence created for program that explores the impact of immunotherapies for lung cancer.

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Tagged: biology, cancer, hybrid medical, immune system, immunology, immunotherapy, killer cells, medical animation, science visuals, scientific animation, tumor cells

One of a few sequences we produced for the film “Burden of Genius.”

This documentary explores the life of Dr. Thomas Starzl, a man many call the greatest surgeon of the 20th century and “the father of modern transplantation.”

In 1967, Dr. Starzl stunned the world with the first successful liver transplantation.

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Tagged: biology, documentary, heart, hybrid medical, liver, liver transplant, medical animation, organ transplant, science visuals, transplant, transplant survivor, visual effects

AnatomyAR+ augmented reality app for #MERGECube, available on MERGE Miniverse.

We made this video for our augmented reality app; featuring the most thoughtful (yet tough!) critics we could find. We are currently working on some updates and enhancements.

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Tagged: AR, ARVRinEDU, augmented reality, biology, ed tech, extended reality, kids in AR, MERGE Cube, mixed reality, science education, science visuals, VR, XR

Micro-landscape view of respiratory cells, an accumulating layer of mucus, and Bordetella pertussis bacteria releasing toxins.

A coughing event is occurring here, displacing mucus, the bacteria, and debris.

Also known as whooping cough, pertussis is a highly contagious airborne disease that spreads simply through the coughs and sneezes of an infected person.

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Tagged: biology, bordetella pertussis bacteria, hybrid medical, microbiology, mucus, respiratory cells, science visuals, scientific animation, whooping cough

Excerpt from animation elaborating on the science behind a new sensor technology that measures glucose levels in diabetes. The benefit of the device: no daily finger prick, and testing of glucose levels in a less painful and more efficient manner. Pretty cool.

In this sequence, we zoom down to the surface of the flexible filament to get a closer look at the micro cross-linked polymer matrix environment. As the camera travels through the matrix, glucose molecules can be seen landing, leading to signaling down the length of the cross-linked polymer chain, and reaching the floor of the sensor electrode.

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Tagged: blood glucose, blood glucose control, blood glucose levels, diabetes, diabetics, hybrid medical, medical animation, science visuals, scientific animation

Tagged: antibodies, antibody, antibody animation, antibody drug conjugate, biology, biopharmaceutical drugs, biotechnology, Biotherapeutic, cancer, cancer immunotherapy, cell biology, drug payload, hybrid medical, hybrid medical animation, immunotherapy, medical animation, Medical science, medical visualisation, medicine, monoclonal, monoclonal antibodies, pharma, science, science art, science visuals, scientific animation, therapeutic, visual science

Animation created for the Synexis BioDefense System, a cutting-edge device that converts naturally occurring oxygen and humidity in the air to Dry Hydrogen Peroxide (H2O2), otherwise known as DHP™.

This unique molecule works continuously to attack the mold, bacteria and viruses (including SARS-CoV-2) that hide in any type of indoor space.

Our job was to visualize the breakdown and conversion of particles to be converted into DHP, as well as show how DHP molecules are drawn to and destroy various types of viruses, bacteria and mold.

We collaborated closely with our client regarding how the DHP engages with (and destroys) each kind of pathogen, as well as behavior of subatomic particles in the breakdown-and-conversion process inside the catalyst space.

For the complete video, visit synexis.com

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Tagged: bacteria, bioart, biodefense, continuous clean, DHP, Dry hydrogen peroxide, health & wellness, hybrid medical, Innovative technology, medical animation, medical marketing, medical visualisation, microbes, microbiology, mold, naturally safe, science, science art, science visuals, scientific animation, Synexis, virology, viruses, visual effects

The monoclonal antibody has become instrumental for the treatment of multiple myeloma.

In this sequence, monoclonal antibodies are seen targeting CD38, a protein commonly expressed on the surface of cancerous plasma cells.

Activation of the complement system triggers the formation of pores in the cellular membrane, leading to cell death.

A goal for this sequence was to explore a visual approach that resembled a deep sea look & feel, including planktonic soft-bodied organisms and other invertebrate animals that live near the ocean floor.

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Tagged: antibodies, antibody, antigen, biology class, blood cancer, cancer, CD38, CD38 antibodies, hybrid medical, immune system, mAb, medical animation, medical illustration, medical marketing, medical visualization, monoclonal, multiple myeloma, myeloid, pharmaceutical animation, science, science art, science visuals, scientific animation