Sickle cell vaso-occlusion

Nov 02, 2020

Here inside this blood vessel, the circulation of red blood cells is obstructed by sickled red blood cells aggregating, sticking together, and leading to an event known as a vaso-occlusive crisis — a central characteristic of sickle cell disease (SCD)

As we zoom out, we are able to see more damage being done in other microvessels.

Sickled red blood cells promote inflammation, obstruct the vasculature, injure the endothelium, and may lead to ischemic damage in vital organs.

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The endocannabinoid system (ECS)

Jan 15, 2021

1.5-minute animation created for CME event. 

Our assignment included the development of the science story and creation of key events that would inform and educate viewers on the physiologic functions associated with the endocannabinoid system (ECS), the role of CB1 retrograde signaling, as well as the enzymes involved in the degradation of endocannabinoids.

We had the pleasure and honor of collaborating closely with the speaker of this event; she is also noted for her discovery of the CB1 receptor for cannabinoid agonists.

The target audience included neurologists, primary care physicians, and pediatricians.

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Targeting DNA methylation

Mar 04, 2021

Sequence from project that provides insight on the role aberrant DNA methylation has in the abnormalities responsible for cancer cell growth, especially hematological malignancies such as leukemia, lymphoma, and multiple myeloma.

In this sequence, we begin with a view of “normal” DNA methylation, and then change to a view of hypermethylation underway.

Eventually, decitabine – a hypomethylating agent – can be seen moving into place and blocking DNA methyltransferase (DNMT), leading to the degradation of DNMT and eventual hypomethylation.

Targeting DNA methylation with DNA hypomethylating agents (HMAs) acts to reprogram tumor cells to a more normal-like state.

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sleep animation

The healing power of sleep

May 17, 2021

Sequence from immersive 1.5-minute 360° animation where we explore the benefits of sleep.

Here within the neural microspace of the brain, we depict the “cleansing system” of the brain: the glymphatic system. 

Just like the rest of your body, the brain accumulates waste. Recent discoveries have shown that cerebral spinal fluid “flushes” debris and metabolic toxins out of the neural microspace during the deep sleep phase. 

We also watch the heart beating (and lungs breathing) inside the chest cavity and discuss the role of sleep in reducing your risk for cardiovascular diseases.

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Medications for type 2 diabetes

Jan 12, 2022

Patient education animations created for WebMD that explore common medications for type 2 diabetes.

Because each treatment works in a unique way, our task was to bring three medications to life, creating an easy-to-understand mechanism of action story for each science story.

The three medications highlighted on the WebMD website: Metformin, Dipeptidyl Peptidase-4 (DPP-4), and SGLT2 Inhibitors. 

These are selected segments from the larger productions.

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The pathophysiology of sickle cell disease

Jan 15, 2022

Segment from a 4-minute animation that explores the pathophysiology of sickle cell disease and the progressive, tissue-damaging effects of chronic hemolysis and anemia.

Our assignment: visually depict several key critical aspects of the SCD story, such as hemoglobin S (HbS) polymerization, red blood cell sickling and tethering, vaso-occlusion, and chronic hemolysis.

Sickled red blood cells promote inflammation, obstruct the vasculature, injure the endothelium, and may lead to ischemic damage in vital organs.

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4D Theater “Ride the Rails” Experience

Jul 11, 2017

A few selected segments from an 8-minute animation produced specially for client’s trade show “4D Multisensory” installation.

The 3D interactive ride was featured at the ATS International Conference, the home of pulmonary, critical care and sleep professionals. Attendees experienced a stereoscopic, 3D monorail-style journey through two “branded” cities, learning more about two different patient therapies for COPD.

The XD Theater Experience is a self-contained, motion-simulated, stereoscopic 3D interactive ride often implemented for high-end, media-based trade show attractions.

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CD38 antibodies inducing cell death

Feb 20, 2022

The monoclonal antibody has become instrumental for the treatment of multiple myeloma.

In this sequence, monoclonal antibodies are seen targeting CD38, a protein commonly expressed on the surface of cancerous plasma cells.

Activation of the complement system triggers the formation of pores in the cellular membrane, leading to cell death.

A goal for this sequence was to explore a visual approach that resembled a deep sea look & feel, including planktonic soft-bodied organisms and other invertebrate animals that live near the ocean floor.

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New hybrid promotional reel

Nov 01, 2017

We are excited to release our new demo reel!

A collection of some of our favorite and latest work, featuring segments from medical animation projects we have produced over the past couple of years.

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Pneumonia infection

Feb 20, 2022

Deep in the lungs, we can see the clusters of tiny air sacs — the alveoli — becoming inflamed and filling with pus, making it difficult to breathe.

Pneumonia is an infection of the lungs caused by bacteria, viruses, or even fungi.

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Protecting against concussions

Dec 28, 2017

A couple of excerpts from a video production that explores a new advancement in preventing brain injury; specifically, the occurrence of brain injury caused by a concussive blow to the head.

The Q-Collar, developed by Q30 Innovations, assists the body’s own physiology, creating a “bubble-wrap” effect for the brain.

One key visual component of this project involved working closely with the client to execute their concept of slosh mitigation.

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Diabetic nephropathy & chronic kidney disease

Feb 21, 2022

A few frames from animation that depicts the progression of diabetic nephropathy, a driver of chronic kidney disease in people with diabetes. 

Here in the glomerulus, the images show progressive damage to the tubules, damage to podocytes (including loss of them), and scarring as a result of mesangial cells excreting extracellular matrix. 

The last image depicts contracted, granular kidneys from long-term hypertension.

Animation was created for client’s episode on chronic kidney disease and the relationship between type 2 diabetes and cardiovascular risk in patients with advanced CKD.

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Experience Virtual Inflammation in the Vive

Jan 02, 2018

VR experience examining the pathogenesis and inflammatory cycle of psoriatic arthritis.

What does virtual reality provide that a linear video cannot? For this MOA, we immerse the viewer into the inflammatory cycle of psoriatic arthritis and reiterate the story in a non-linear fashion — allowing users the ability to roam around and explore as they wish.

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Attacking pathogens with biodefense technology

Feb 22, 2022

Animation created for the Synexis BioDefense System, a cutting-edge device that converts naturally occurring oxygen and humidity in the air to Dry Hydrogen Peroxide (H2O2), otherwise known as DHP™.

This unique molecule works continuously to attack the mold, bacteria and viruses (including SARS-CoV-2) that hide in any type of indoor space.

Our job was to visualize the breakdown and conversion of particles to be converted into DHP, as well as show how DHP molecules are drawn to and destroy various types of viruses, bacteria and mold.

We collaborated closely with our client regarding how the DHP engages with (and destroys) each kind of pathogen, as well as behavior of subatomic particles in the breakdown-and-conversion process inside the catalyst space.

For the complete video, visit synexis.com

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Immunotherapy in lung cancer

Feb 15, 2018

Activated T cells of the immune system targeting and destroying tumor cells. Once lysis occurs, the T cell moves to another cancer cell and repeats the process.

Sequence created for program that explores the impact of immunotherapies for lung cancer.

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mAb targeting multiple myeloma

Feb 22, 2022

Sequence from 5-minute MOA that provides insight and details for a monoclonal antibody (mAb) designed to induce programmed tumor cell death (apoptosis) and immunomodulatory activity.

For this mechanism of action video, our task was to create a science story that would depict several key features: how the mAb finds and binds to myeloma cells and exposes them for elimination, how it boosts cells of the immune system, and how this targeted immunotherapy can kill myeloma cells directly.

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Let the phlegm fly!

Jul 08, 2018

Micro-landscape view of respiratory cells, an accumulating layer of mucus, and Bordetella pertussis bacteria releasing toxins.

A coughing event is occurring here, displacing mucus, the bacteria, and debris.

Also known as whooping cough, pertussis is a highly contagious airborne disease that spreads simply through the coughs and sneezes of an infected person.

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CAR T-cell animation

A CAR T-cell therapy targeting B-cell maturation antigen (BCMA)

Apr 21, 2022

A few selected segments from a 6-minute animation created for a first-in-class B-cell maturation antigen (BCMA)-directed personalized immunotherapy called chimeric antigen receptor (CAR) T-cell therapy.

In this CAR T therapy, the T cells are engineered to target a protein called BCMA, which is found in abundance on multiple myeloma cells, but is absent from nearly all normal cells.

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New sensor technology that measures glucose levels in diabetes

Dec 14, 2018

Excerpt from animation elaborating on the science behind a new sensor technology that measures glucose levels in diabetes. The benefit of the device: no daily finger prick, and testing of glucose levels in a less painful and more efficient manner. Pretty cool.

In this sequence, we zoom down to the surface of the flexible filament to get a closer look at the micro cross-linked polymer matrix environment. As the camera travels through the matrix, glucose molecules can be seen landing, leading to signaling down the length of the cross-linked polymer chain, and reaching the floor of the sensor electrode.

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Fat cell enlargement & type 2 diabetes

Apr 22, 2022

Fat cell enlargement in obesity is related to insulin resistance and type 2 diabetes.

In this sequence, we travel into the visceral fat and see an active environment – teeming with overstressed, damaged fat cells, vasculature, and immune cells.

Stress on these hypertrophic adipocytes results in lipid spillover (fatty acid release) into the circulation, as well as proinflammatory cytokine release and immune cell recruitment.

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